Cloning and tissue-specific expression of cardiac and brain L-type calcium channels
نویسندگان
چکیده
منابع مشابه
Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels.
The cloning of the cDNA for the alpha 1 subunit of L-type calcium channels revealed that at least two genes (CaCh1 and CaCh2) exist which give rise to several splice variants. The expression of mRNA for these alpha 1 subunits and the skeletal muscle alpha 2/delta, beta and gamma subunits was studied in rabbit tissues and BC3H1 cells. Nucleic-acid-hybridization studies showed that the mRNA of al...
متن کاملTissue-specific expression of calcium channels.
The high-voltage-activated calcium channel is a multimeric protein complex containing α(1), α(2)/δ, β, and γ subunits. The α(1) subunit is the ion conduction channel and contains the binding sites for calcium channel blockers and toxins. Three genes code for distinct L-type, dihydropyridine-sensitive α(1) subunits; one gene codes for the neuronal P-type (Purkinje) α(1) subunit; and one gene cod...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Stimulation of cardiac L-type calcium channels by extracellular ATP.
The co-release of ATP with norepinephrine from sympathetic nerve terminals in the heart may augment adrenergic stimulation of cardiac Ca(2+) channel activity. To test for a possible direct effect of extracellular ATP on L-type Ca(2+) channels, single channels were reconstituted from porcine sarcolemma into planar lipid bilayers so that intracellular signaling pathways could be controlled. Extra...
متن کاملInhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids.
Epoxyeicosatrienoic acids (EETs), products of the cytochrome P-450 monooxygenase metabolism of arachidonic acid, can regulate the activity of ion channels. We examined the effects of EETs on cardiac L-type Ca2+ channels that play important roles in regulating cardiac contractility, controlling heart rate, and mediating slow conduction in normal nodal cells and ischemic myocardium. Our experimen...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1990
ISSN: 0735-1097
DOI: 10.1016/0735-1097(90)91736-e